NANCY MORAN LAB
A. kondoi

Research

My current work with Dr. Nancy Moran involves identifying and characterizing mechanisms of host-symbiont interaction within the aphid-Buchnera model system. In particular, I am interested in how the host regulates the size of its Buchnera population, balancing the cost and benefit of harboring symbiotic bacteria. I am investigating transcriptomic differences between aphid sibships displaying variable Buchnera abundances to identify genes that might be involved in regulating symbiont population size, while using biochemistry and synthetic biology to evaluate the role of genes of interest in symbiosis.

Professional History

Publications

Smith, T. E., Pond, C. D., Pierce, E., Harmer, Z., Kwan, J., Zachariah, M., Harper, M. K., Wyche, T., Matainaho, T. K., Bugni, T. S., Barrows, L. R., Ireland, C. M., Schmidt, E. W. (2018) Direct access to chemical diversity from the uncultivated symbionts of small marine animals. Nat. Chem. Biol. (Accepted)

Smith, T. E. (2017) Biogenetic relationships of bioactive sponge merotriterpenoids. Mar. Drugs. 15(9): 285.

Smith, T. E., Hong, W., Zachariah, M. M., Harper, M. K., Matainaho, T. K., Van Wagoner, R. M., Ireland, C. M., Vershinin, M. (2013) Single molecule inhibition of kinesin by adociasulfate-13 and -14 from the sponge Cladocroce aculeata. Proc. Nat. Acad. Sci. USA. 110(47): 18880–18885.

Smith, N. J., Hone, A. J., Memon, T., Bossi, S., Smith, T. E., McIntosh, J. M., Olivera, B. M., Teichert, R. W. (2013) Comparative functional expression of nAChR subtypes in rodent DRG neurons. Front. Cell. Neurosci. 7:255.