NANCY MORAN LAB
A. kondoi

Research


Professional History

Education

Publications

J. E. Powell, Z. Carver, S. P. Leonard, N. A. Moran, Field-Realistic Tylosin Exposure Impacts Honey Bee Microbiota and Pathogen Susceptibility, Which Is Ameliorated by Native Gut Probiotics. Microbiology Spectrum (2021), doi:10.1128/spectrum.00103-21.

K. M. Elston, S. P. Leonard, P. Geng, S. B. Bialik, E. Robinson, J. E. Barrick, Engineering insects from the endosymbiont out. Trends Microbiol. (2021), doi:10.1016/j.tim.2021.05.004.

S. P. Leonard, J. E. Powell, J. Perutka, P. Geng, L. C. Heckmann, R. D. Horak, B. W. Davies, A. D. Ellington, J. E. Barrick, N. A. Moran. 2020. Engineered symbionts activate honey bee immunity and limit pathogens. Science 367: 573-576. PMID: 32001655

B. Zhang, S. P. Leonard, Y. Li, N. A. Moran. 2019. Obligate bacterial endosymbionts limit thermal tolerance of insect host species. Proc Natl Acad Sci U S A. 2019 Nov 18. pii: 201915307. PMID: 31740601

P. Geng, S. P. Leonard, D. M. Mishler, J. E. Barrick. 2019. Synthetic Genome Defenses against Selfish DNA Elements Stabilize Engineered Bacteria against Evolutionary Failure. ACS Synth Biol. 8: 521-531. PMID: 30703321

H. Zheng, M. I. Steele, S. P. Leonard, E. V. S. Motta, N. A. Moran. 2018. Honey bees as models for gut microbiota research. Lab Anim (NY). 47: 317-325. PMID: 30353179

S. P. Leonard, J. Perutka, J. E. Powell, P. Geng, D. D. Richhart, M. Byrom, S. Kar,B. W. Davies, A. D. Ellington, N. A. Moran, J. E. Barrick. 2018. Genetic engineering of bee gut microbiome bacteria with a toolkit for modular assembly of broad-host-range plasmids. ACS Synth Biol. 7: 1279-1290. PMID: 29608282

A. T. Tucker, S. P. Leonard, C. D. Dubois, G. K. Knauf, A. L. Cunningham, C. O. Wilke, M. S. Trent, B. W. Davies. 2017. Next-generation antimicrobial discovery through bacterial self- screening of surface-displayed peptide libraries. Cell. 172(3):618-628.e13. PMID: 29307492

J. E. Powell*, S. P. Leonard*, W. K. Kwong*, P. Engel and N. A. Moran. 2016. Genome-wide screen identifies host colonization determinants in a bacterial gut symbiont. Proc Natl Acad Sci U S A.113:13887-13892. PMID: 27849596. *equal contributions

J. W. Monk, S. P. Leonard, C. W. Brown, M. J. Hammerling, C. Mortensen, A. E. Gutierrez, N. Y. Shin, E. Watkins, D. M. Mishler and J. E. Barrick. 2016. Rapid and inexpensive evaluation of nonstandard amino acid incorporation in Escherichia coli. ACS Synthetic Biology 6(1):45–54. PMID: 27648665

B. R. Jack, S. P. Leonard, D. M. Mishler, B. A. Renda, D. Leon, G. A. Suárez and J. E. Barrick. 2015. Predicting the genetic stability of engineered DNA sequences with the EFM Calculator. ACS Synthetic Biology 4(8):939–943. PMID: 26096262

B. P. Arulanandam, S. L. Chetty, J. Yu, S. Leonard, K. Klose, J. Seshu, A. Cap, J. J. Valdes, J. P. Chambers. 2012. Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase. Journal of Biological Chemistry 287(44):37185-37194. PMID: 22923614