neurocranium
Fish
  
The University of Texas at Austin

 
 
Facial Development in Zebrafish

The image on the right shows a normal palate and upper jaw of a five day old zebrafish.

 

 

 

Hypomorphic lesions in sonic hedgehog cause a loss of the palate and fusions of the upper jaw across the midline, as seen in the image to the right.

   SHH Hypomorph
Normal Zebrafish Face   PDGFRA - face
Normal zebrafish face   pdgfra mutant fish face notice the cleft lip

Kaede Protein

Fate mapping of pre-migratoy palatal precursors by photoconversion of Kaede protein

single cell electroporation

Fate mapping of jaw post-migratory precursors by single cell electroporation
Crest cell migration   pdgfra mutant embryo
Crest cell migration is defective in pdgfra mutants shown in this transgenic fish above   In the same pdgfra mutant embryo, transplanted wild type neural crest cells (in red) migrate normally.
 
 

Eberhart Lab. Patterson 528. 2401Speedway. University of Texas at Austin. 78713