UT Virology Club Archive
Nov. 3, 11 AM, MBB 1.210
Nick Meyerson
Dr. Sara Sawyer's Laboratory, UT Austin
Title: "Journal Club Presentation of Permissive secondary mutations enable the evolution of influenza oseltamivir resistance. Jesse Bloom, Lizhi Gong, and David Baltimore, Science. 2010 Jun 4;328(5983):1272-5."
Oct. 6, 11 AM, MBB 1.120
Dr. Jackie Dudley
Title: "Round, round, get around, I get around: how a retroviral protein requires signal peptidase in the ER for trafficking to the nucleus"
Retroviruses have small RNA genomes that must maximize their use of coding information to allow chronic infections of their hosts. Mouse mammary tumor virus (MMTV) is a retrovirus that causes mammary tumors and T-cell lymphomas, but has organizational similarities to HIV-1. We recently have shown that MMTV encodes a functional HIV Rev-like regulatory protein (Rem) with an usually long signal peptide (SP). Rem requires processing in the endoplasmic reticulum and ERAD-associated retrotranslocation of SP to the cytoplasm before SP binding to viral RNA in the nucleolus.
Sept. 1, 11 AM, MBB 1.120:
Larissa Durfee from Jon Huibregtse's Lab.
Title: Conjugation and function of ISG15, an antiviral ubiquitin-like protein.
ISG15 is a ubiquitin-like protein that is strongly induced by type 1 interferons. It is covalently conjugated to hundreds of proteins in interferon-treated cells, however the function and mechanism of "ISGylation" has been an enigma for many years. We will present results indicating that conjugation occurs co-translationally and that target recognition is largely nonspecific. The big quesiton: how is this related to ISG15's antiviral function?
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